vel voluptate quaerat est laudantium velit sed. necessitatibus odit consequuntur minus quia quo asperiores doloribus nemo repellat cum qui autem labore. dolores alias quis et reprehenderit cum quis co
7/30/2024
[email protected] (7/30/2024)
vel voluptate quaerat est laudantium velit sed. necessitatibus odit consequuntur minus quia quo asperiores doloribus nemo repellat cum qui autem labor...
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The findings in non-human primates could shed light on how our brains develop facial recognition skills.
7/19/2024
NIH researchers discover a new face-detecting brain circuit (7/19/2024)
The findings in non-human primates could shed light on how our brains develop facial recognition skills...
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In a new analysis of data, researchers at the National Institutes of Health (NIH) have found that taking a daily supplement containing antioxidant vitamins and minerals slows progression of late-stage dry age-related macular degeneration (AMD)
7/19/2024
Supplements slow disease progression during late stage of “dry” age-related macular degeneration (7/19/2024)
In a new analysis of data, researchers at the National Institutes of Health (NIH) have found that taking a daily supplement containing antioxidant vit...
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NIH study highlights need for greater education, training, and policies to increase adoption of evidence-based care for addiction among physicians
7/19/2024
Doctors reluctant to treat addiction most commonly report “lack of institutional support” as barrier (7/19/2024)
NIH study highlights need for greater education, training, and policies to increase adoption of evidence-based care for addiction among physician...
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NIH-funded study of conduct disorder identifies new brain areas associated with the disorder, offering future directions for research efforts and clinical practice
7/19/2024
Youth with conduct disorder show widespread differences in brain structure (7/19/2024)
NIH-funded study of conduct disorder identifies new brain areas associated with the disorder, offering future directions for research efforts and clin...
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Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variants
7/19/2024
NIH-sponsored trial of nasal COVID-19 vaccine opens (7/19/2024)
Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variant...
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qui omnis quia vel provident aut laboriosam ab corrupti quasi non voluptatem magni voluptatem at optio nemo. architecto soluta ipsa facere et labore. aut minus autem non ea non possimus nemo sit at fa
7/10/2024
[email protected] (7/10/2024)
qui omnis quia vel provident aut laboriosam ab corrupti quasi non voluptatem magni voluptatem at optio nemo. architecto soluta ipsa facere et labore. ...
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The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enterovirus D68 (EV-D68), which can cause severe respiratory and neurological diseases such as acute flaccid myelitis (AFM)
7/8/2024
NIH-sponsored trial of enterovirus D68 therapeutic begins (7/8/2024)
The National Institutes of Health (NIH) is sponsoring a clinical trial to evaluate the safety of an investigational monoclonal antibody to treat enter...
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Findings come from an NIH analysis of more than two decades of dietary data from 390,124 U.S. adults
7/8/2024
For healthy adults, taking multivitamins daily is not associated with a lower risk of death (7/8/2024)
Findings come from an NIH analysis of more than two decades of dietary data from 390,124 U.S. adult...
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The findings in non-human primates could shed light on how our brains develop facial recognition skills
7/8/2024
NIH researchers discover a new face-detecting brain circuit (7/8/2024)
The findings in non-human primates could shed light on how our brains develop facial recognition skill...
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NIH-supported study reveals crucial need to increase public awareness that medications for opioid use disorder can be prescribed in primary care settings
7/8/2024
Most Americans don’t know that primary care physicians can prescribe addiction treatment (7/8/2024)
NIH-supported study reveals crucial need to increase public awareness that medications for opioid use disorder can be prescribed in primary care setti...
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Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variants
7/8/2024
NIH-sponsored trial of nasal COVID-19 vaccine opens (7/8/2024)
Candidate vaccine could provide enhanced breadth of protection against emerging SARS-CoV-2 variant...
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est odio maiores aperiam velit voluptatum error quaerat qui et rerum. aspernatur vel laboriosam neque sint et tempore laboriosam tempora commodi modi deleniti velit tempore rerum harum molestiae quide
6/28/2024
[email protected] (6/28/2024)
est odio maiores aperiam velit voluptatum error quaerat qui et rerum. aspernatur vel laboriosam neque sint et tempore laboriosam tempora commodi modi ...
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A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin use and lower risk of death. The study
6/27/2024
For healthy adults, taking multivitamins daily is not associated with a lower risk of death (6/27/2024)
A large analysis of data from nearly 400,000 healthy U.S. adults followed for more than 20 years has found no association between regular multivitamin...
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The prevalence of chronic hypertension in pregnancy in the United States doubled from 2007-2021, but only about 60% of those with the potentially life-threatening condition were treated with antihypertensive medications, according to a National Institutes of Health (NIH)-supported study of nearly 2 million pregnancies. The study
6/27/2024
Chronic hypertension in pregnancy doubled in the U.S. from 2007-2021 (6/27/2024)
The prevalence of chronic hypertension in pregnancy in the United States doubled from 2007-2021, but only about 60% of those with the potentially life...
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The prevalence of chronic hypertension in pregnancy in the United States doubled from 2007-2021, but only about 60% of those with the potentially life-threatening condition were treated with antihypertensive medications, according to a National Institutes of Health (NIH)-supported study of nearly 2 million pregnancies. The study
6/27/2024
Chronic hypertension in pregnancy doubled in the U.S. from 2007-2021 (6/27/2024)
The prevalence of chronic hypertension in pregnancy in the United States doubled from 2007-2021, but only about 60% of those with the potentially life...
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The National Institutes of Health (NIH) is investing approximately $30 million in total over fiscal years 2024 and 2025 to pilot a national primary care research network that integrates clinical research with community-based primary care
6/27/2024
NIH launches $30 million pilot to test feasibility of a national primary care research network (6/27/2024)
The National Institutes of Health (NIH) is investing approximately $30 million in total over fiscal years 2024 and 2025 to pilot a national primary ca...
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In a small study, researchers have discovered how a set of genes could cause neurons to die in sporadic amyotrophic lateral sclerosis (ALS). The results, published in Nature Aging(link is external)
6/27/2024
Scientists identify genes linked to brain cell loss in ALS (6/27/2024)
In a small study, researchers have discovered how a set of genes could cause neurons to die in sporadic amyotrophic lateral sclerosis (ALS). The resul...
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In a small study, researchers have discovered how a set of genes could cause neurons to die in sporadic amyotrophic lateral sclerosis (ALS). The results, published in Nature Aging(link is external), provide insight into the root causes of ALS and may lead to new ways to halt disease progression. The study was funded by the National Institutes of Health (NIH)
6/22/2024
Scientists identify genes linked to brain cell loss in ALS (6/22/2024)
In a small study, researchers have discovered how a set of genes could cause neurons to die in sporadic amyotrophic lateral sclerosis (ALS). The resu...
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The prevalence of chronic hypertension in pregnancy in the United States doubled from 2007-2021, but only about 60% of those with the potentially life-threatening condition were treated with antihypertensive medications
6/22/2024
Chronic hypertension in pregnancy doubled in the U.S. from 2007-2021 (6/22/2024)
The prevalence of chronic hypertension in pregnancy in the United States doubled from 2007-2021, but only about 60% of those with the potentially life...
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A genomic analysis co-led by NIH suggests that the DNA a woman is born with may influence how her cells respond to chromosomal abnormalities acquired with aging.
6/22/2024
Inherited genetic factors may predict the pattern of X chromosome loss in older women (6/22/2024)
A genomic analysis co-led by NIH suggests that the DNA a woman is born with may influence how her cells respond to chromosomal abnormalities acquired ...
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Understanding virus biology, advancing detection, treatment and prevention strategies are key objectives.
6/22/2024
NIH releases H5N1 influenza research agenda (6/22/2024)
Understanding virus biology, advancing detection, treatment and prevention strategies are key objectives...
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The amount of infectious H5N1 influenza viruses in raw milk rapidly declined with heat treatment in laboratory research.
6/22/2024
Infectious H5N1 influenza virus in raw milk rapidly declines with heat treatment (6/22/2024)
The amount of infectious H5N1 influenza viruses in raw milk rapidly declined with heat treatment in laboratory research...
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voluptas enim deserunt et incidunt quaerat. non autem laudantium dignissimos sed aut voluptatem maxime nostrum rerum. ut alias qui modi fugiat est veritatis saepe aut. doloremque ut corrupti modi libe
6/17/2024
[email protected] (6/17/2024)
voluptas enim deserunt et incidunt quaerat. non autem laudantium dignissimos sed aut voluptatem maxime nostrum rerum. ut alias qui modi fugiat est ver...
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Researchers have identified inherited genetic variants that may predict the loss of one copy of a woman’s two X chromosomes as she ages, a phenomenon known as mosaic loss of chromosome X, or mLOX.
6/13/2024
Inherited genetic factors may predict the pattern of X chromosome loss in older women (6/13/2024)
Researchers have identified inherited genetic variants that may predict the loss of one copy of a woman’s two X chromosomes as she ages, a phenomenon ...
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In a proof-of-concept study, researchers at the National Institutes of Health (NIH) have developed an artificial intelligence (AI) tool that uses routine clinical data, such as that from a simple blood test, to predict whether someone’s cancer will respond to immune checkpoint inhibitors, a type of immunotherapy drug that helps immune cells kill cancer cells
6/13/2024
NIH scientists develop AI tool to predict how cancer patients will respond to immunotherapy (6/13/2024)
In a proof-of-concept study, researchers at the National Institutes of Health (NIH) have developed an artificial intelligence (AI) tool that uses rout...
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The National Institutes of Health (NIH) is investing approximately $30 million in total over fiscal years 2024 and 2025 to pilot a national primary care research network that integrates clinical research with community-based primary care. The new initiative called Communities Advancing Research Equity for Health – or CARE for Health – seeks to improve access to clinical research to inform medical care
6/13/2024
NIH launches $30 million pilot to test feasibility of a national primary care research network (6/13/2024)
The National Institutes of Health (NIH) is investing approximately $30 million in total over fiscal years 2024 and 2025 to pilot a national primary ca...
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Two clinical trials have launched to examine a novel long-acting form of HIV pre-exposure prophylaxis (PrEP) in cisgender women and people who inject drugs. The mid-stage studies will assess the safety, acceptability, and pharmacokinetics (how a drug moves through the body) of lenacapavir, an antiretroviral drug administered by injection every six months.
6/13/2024
U.S. clinical trials begin for twice-yearly HIV prevention injection (6/13/2024)
Two clinical trials have launched to examine a novel long-acting form of HIV pre-exposure prophylaxis (PrEP) in cisgender women and people who inject ...
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A team of researchers funded by the National Institutes of Health have generated the first complete chromosome sequences from non-human primates
6/13/2024
Scientists generate the first complete chromosome sequences from non-human primates (6/13/2024)
A team of researchers funded by the National Institutes of Health have generated the first complete chromosome sequences from non-human primate...
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Two clinical trials have launched to examine a novel long-acting form of HIV pre-exposure prophylaxis (PrEP) in cisgender women and people who inject drugs.
6/6/2024
U.S. clinical trials begin for twice-yearly HIV prevention injection (6/6/2024)
Two clinical trials have launched to examine a novel long-acting form of HIV pre-exposure prophylaxis (PrEP) in cisgender women and people who inject ...
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A team of researchers funded by the National Institutes of Health have generated the first complete chromosome sequences from non-human primates
6/6/2024
Scientists generate the first complete chromosome sequences from non-human primates (6/6/2024)
A team of researchers funded by the National Institutes of Health have generated the first complete chromosome sequences from non-human primate...
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A five-minute cognitive assessment coupled with a decision tree embedded in electronic medical records, known as 5-Cog, improved dementia diagnosis and care, based on a clinical trial funded by the National Institutes of Health (NIH) and conducted in an urban primary care setting
6/6/2024
New clinical assessment tool improves dementia care actions in primary care patients (6/6/2024)
A five-minute cognitive assessment coupled with a decision tree embedded in electronic medical records, known as 5-Cog, improved dementia diagnosis an...
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A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyendocrine syndrome type 1 (APS-1). Researchers identified the treatment based on their discovery that the syndrome is linked to elevated levels of interferon-gamma (IFN-gamma), a protein involved in immune system responses, providing new insights into the role of IFN-gamma in autoimmunity
6/6/2024
Existing drug shows promise as treatment for rare genetic disorder (6/6/2024)
A drug approved to treat certain autoimmune diseases and cancers successfully alleviated symptoms of a rare genetic syndrome called autoimmune polyend...
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Researchers have, for the first time, visualized the full network of blood vessels across the cortex of awake mice, finding that blood vessels rhythmically expand and contract leading to “waves” washing across the surface of the brain
6/6/2024
Blood flow makes waves across the surface of the mouse brain (6/6/2024)
Researchers have, for the first time, visualized the full network of blood vessels across the cortex of awake mice, finding that blood vessels rhythmi...
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Mice administered raw milk samples from dairy cows infected with H5N1 influenza experienced high virus levels in their respiratory organs and lower virus levels in other vital organs, according to findings published in the New England Journal of Medicine
5/25/2024
High H5N1 influenza levels found in mice given raw milk from infected dairy cows (5/25/2024)
Mice administered raw milk samples from dairy cows infected with H5N1 influenza experienced high virus levels in their respiratory organs and lower vi...
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A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with and without mental disorders. These maps detail the many regulatory elements that coordinate the brain’s biological pathways and cellular functions. The research, supported the National Institutes of Health (NIH)
5/25/2024
Scientists map networks regulating gene function in the human brain (5/25/2024)
A consortium of researchers has produced the largest and most advanced multidimensional maps of gene regulation networks in the brains of people with ...
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Scientists at the National Institutes of Health (NIH) have discovered that the presence of a benign nail abnormality may lead to the diagnosis of a rare inherited disorder that increases the risk of developing cancerous tumors of the skin, eyes
5/25/2024
Benign nail condition linked to rare syndrome that greatly increases cancer risk (5/25/2024)
Scientists at the National Institutes of Health (NIH) have discovered that the presence of a benign nail abnormality may lead to the diagnosis of a ra...
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Led by researchers at the National Institutes of Health (NIH), a team of scientists has uncovered the complex molecular mechanisms underlying neurodegenerative disorders linked to the gene PNPLA6
5/25/2024
Scientists unravel genetic basis for neurodegenerative disorders that affect vision (5/25/2024)
Led by researchers at the National Institutes of Health (NIH), a team of scientists has uncovered the complex molecular mechanisms underlying neurodeg...
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SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-supported study has found. The research
5/25/2024
(5/25/2024)
SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-sup...
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Researchers have discovered that choline, an essential nutrient vital for brain health, is actively transported from the bloodstream into the brain by a protein. The findings may inform the development of new drugs that take advantage of this mechanism to treat brain disorders
5/22/2024
Scientists discover how an essential nutrient enters the brain (5/22/2024)
Researchers have discovered that choline, an essential nutrient vital for brain health, is actively transported from the bloodstream into the brain by...
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Scientists at the National Institutes of Health (NIH) have discovered that the presence of a benign nail abnormality may lead to the diagnosis of a rare inherited disorder that increases the risk of developing cancerous tumors of the skin, eyes
5/22/2024
Benign nail condition linked to rare syndrome that greatly increases cancer risk (5/22/2024)
Scientists at the National Institutes of Health (NIH) have discovered that the presence of a benign nail abnormality may lead to the diagnosis of a ra...
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A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chronic wasting disease (CWD) from cervids—deer,
5/22/2024
NIH study shows chronic wasting disease unlikely to move from animals to people (5/22/2024)
A new study of prion diseases, using a human cerebral organoid model, suggests there is a substantial species barrier preventing transmission of chron...
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People were more likely to develop a type of treatment-resistant hypertension when they experienced adverse effects of economic and social conditions that influence individual and group differences in health status, known as social determinants of health. Additionally, this risk was higher among Black American adults than white American adults
5/22/2024
Adverse social determinants of health linked to treatment-resistant hypertension in Black Americans (5/22/2024)
People were more likely to develop a type of treatment-resistant hypertension when they experienced adverse effects of economic and social conditions ...
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Law enforcement seizures of illicit fentanyl increased dramatically in number and size between 2017 to 2023 in the U.S., especially in pill form, according to a new study(link is external) funded by the National Institutes of Health’s (NIH) National Institute on Drug Abuse (NIDA)
5/22/2024
Over 115 million pills containing illicit fentanyl seized by law enforcement in 2023 (5/22/2024)
Law enforcement seizures of illicit fentanyl increased dramatically in number and size between 2017 to 2023 in the U.S., especially in pill form, acco...
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A large research project in young adult rats has found that that all bodily tissues tested respond to exercise training, amounting to over 35,000 biological molecules that respond and adapt to endurance exercise over time, including tissues from organs not usually
5/15/2024
Endurance exercise affects all tissues of the body, even those not normally associated with movement (5/15/2024)
A large research project in young adult rats has found that that all bodily tissues tested respond to exercise training, amounting to over 35,000 biol...
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Findings provide further insight into the complex relationship between sleep disorders and epilepsy
5/15/2024
Low oxygen during sleep and sleep apnea linked to epilepsy in older adults (5/15/2024)
Findings provide further insight into the complex relationship between sleep disorders and epileps...
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Law enforcement seizures of illicit fentanyl increased dramatically in number and size between 2017 to 2023 in the U.S., especially in pill form, according to a new study(link is external) funded by the National Institutes of Health’s (NIH) National Institute on Drug Abuse (NIDA)
5/15/2024
Over 115 million pills containing illicit fentanyl seized by law enforcement in 2023 (5/15/2024)
Law enforcement seizures of illicit fentanyl increased dramatically in number and size between 2017 to 2023 in the U.S., especially in pill form, acco...
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Researchers have discovered that choline, an essential nutrient vital for brain health, is actively transported from the bloodstream into the brain by a protein. The findings may inform the development of new drugs that take advantage of this mechanism to treat brain disorders
5/15/2024
Scientists discover how an essential nutrient enters the brain (5/15/2024)
Researchers have discovered that choline, an essential nutrient vital for brain health, is actively transported from the bloodstream into the brain by...
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Federal study shows lives lost from overdose crisis are felt across generations, emphasizing need to include children and families in support
5/15/2024
More than 321,000 U.S. children lost a parent to drug overdose from 2011 to 2021 (5/15/2024)
Federal study shows lives lost from overdose crisis are felt across generations, emphasizing need to include children and families in suppor...
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The National Institutes of Health (NIH) is revising the application and peer review process for grants that enable external institutions to recruit for research training fellowships. Fellowship training awards are a critical part of the development of the biomedical research workforce. The revised approach for peer review of fellowship applications is designed to enhance participation from strong applicants at smaller schools
4/27/2024
NIH modifies application and review process for fellowship grants to broaden scientific trainee pool (4/27/2024)
The National Institutes of Health (NIH) is revising the application and peer review process for grants that enable external institutions to recruit fo...
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One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country’s six-month malaria season, according to the results of a mid-stage clinical trial. The trial assessed an investigational monoclonal antibody developed by scientists at the National Institutes of Health (NIH), and results appear in The New England Journal of Medicine
4/27/2024
Experimental NIH malaria monoclonal antibody protective in Malian children (4/27/2024)
One injected dose of an experimental malaria monoclonal antibody was 77% effective against malaria disease in children in Mali during the country’s si...
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In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genome(link is external) that are associated with the risk of developing kidney cancer. These insights could one day be used to advance our understanding of the molecular basis of kidney cancer, inform screening efforts for those at highest risk, and identify new drug targets. The study was led by scientists at the National Cancer Institute (NCI), part of the National Institutes of Health (NIH).
4/27/2024
Analysis identifies 50 new genomic regions associated with kidney cancer risk (4/27/2024)
In a new analysis of genetic susceptibility to kidney cancer, an international team of researchers has identified 50 new areas across the genome(lin...
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Secure data from more than 14,000 adults who participate in National Institutes of Health observational research on long COVID are now available to authorized researchers through BioData Catalyst (BDC). BDC is a cloud-based ecosystem developed by the National Heart, Lung, and Blood Institute (NHLBI), part of NIH, to accelerate research on heart, lung, blood, and sleep disorders. The research on long COVID — broadly defined(link is external) as signs, symptoms, or conditions that persist or develop for at least four weeks after an infection from the virus that causes COVID-19 — is provided through the NIH Researching COVID to Enhance Recovery (NIH RECOVER) Initiative
4/27/2024
NIH RECOVER makes long COVID data easier to access (4/27/2024)
Secure data from more than 14,000 adults who participate in National Institutes of Health observational research on long COVID are now available to au...
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The National Institutes of Health (NIH) will increase annual pay levels for predoctoral and postdoctoral scholars at NIH-funded external institutions who are recipients of the Ruth L. Kirschstein National Research Service Awards (NRSA)
4/27/2024
NIH to increase pay levels for pre- and postdoctoral scholars at grantee institutions (4/27/2024)
The National Institutes of Health (NIH) will increase annual pay levels for predoctoral and postdoctoral scholars at NIH-funded external institutions ...
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The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry age-related macular degeneration (AMD), according to a phase II clinical study at the National Eye Institute (NEI), part of the National Institutes of Health.
3/22/2024
Inflammation-reducing drug shows no benefit for dry age-related macular degeneration in NIH trial (3/22/2024)
The drug minocycline, an antibiotic that also decreases inflammation, failed to slow vision loss or expansion of geographic atrophy in people with dry...
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Researchers at the National Institutes of Health (NIH) have discovered that symptoms of attention-deficit/hyperactivity disorder (ADHD) are tied to atypical interactions between the brain’s frontal cortex and information processing centers deep in the brain. The researchers examined more than 10,000 functional brain images of youth with ADHD and published their results in the American Journal of Psychiatry. The study was led by researchers at NIH’s National Institute of Mental Health (NIMH) and National Human Genome Research Institute.
3/22/2024
NIH researchers identify brain connections associated with ADHD in youth (3/22/2024)
Researchers at the National Institutes of Health (NIH) have discovered that symptoms of attention-deficit/hyperactivity disorder (ADHD) are tied to at...
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An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well tolerated and showed signs of therapeutic benefit in a clinical trial led by the National Institutes of Health (NIH). Currently, there is no treatment for GAN and the disease is usually fatal by 30 years of age. Fourteen children with GAN, ages 6 to 14 years, were treated with gene transfer therapy at the NIH Clinical Center and then followed for about six years to assess safety
3/22/2024
Experimental gene therapy for giant axonal neuropathy shows promise in NIH clinical triall (3/22/2024)
An investigational gene therapy for a rare neurodegenerative disease that begins in early childhood, known as giant axonal neuropathy (GAN), was well ...
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SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-supported study has found. The research, published in the journal Circulation, specifically looked at damage to the hearts of people with SARS-CoV2-associated acute respiratory distress syndrome (ARDS), a serious lung condition that can be fatal. But researchers said the findings could have relevance to organs beyond the heart and also to viruses other than SARS-CoV-2.
3/22/2024
Severe lung infection during COVID-19 can cause damage to the heart (3/22/2024)
SARS-CoV-2, the virus that causes COVID-19, can damage the heart even without directly infecting the heart tissue, a National Institutes of Health-sup...
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Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), successfully alleviated pain and inflammation in a rodent model of endometriosis, according to researchers funded by the National Institutes of Health (NIH). They chose the drug after using a computer algorithm to evaluate nearly 1,300 existing compounds for their ability to reverse gene expression related to endometriosis disease. The study was funded by NIH’s Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
3/22/2024
Repurposed drug shows promise against endometriosis-related pain in animal model (3/22/2024)
Fenoprofen, a nonsteroidal anti-inflammatory drug (NSAID), successfully alleviated pain and inflammation in a rodent model of endometriosis, according...
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Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on the relatively unexplored “dark side” of the neuraminidase (NA) protein head. The antibodies target a region of the NA protein that is common among many influenza viruses, including H3N2 subtype viruses, and could be a new target for countermeasures. The research, led by scientists at the National Institute of Allergy and Infectious Diseases’ Vaccine Research Center, part of NIH, was published today in Immunity
3/2/2024
New antibodies target “dark side” of influenza virus protein (3/2/2024)
Researchers at the National Institutes of Health have identified antibodies targeting a hard-to-spot region of the influenza virus, shedding light on ...
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Frequent cannabis smoking may significantly increase a person’s risk for heart attack and stroke, according to an observational study supported by the National Institutes of Health. The study, published in the Journal of the American Heart Association, uses data from nearly 435,000 American adults, and is among the largest ever to explore the relationship between cannabis and cardiovascular events
3/2/2024
Smoking cannabis associated with increased risk of heart attack, stroke (3/2/2024)
Frequent cannabis smoking may significantly increase a person’s risk for heart attack and stroke, according to an observational study supported by the...
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Results from a large clinical trial funded by the National Institutes of Health show that an intervention for anxiety provided to pregnant women living in Pakistan significantly reduced the likelihood of the women developing moderate-to-severe anxiety, depression, or both six weeks after birth. The unique intervention was administered by non-specialized providers who had the equivalent of a bachelor’s degree in psychology—but no clinical experience. The results suggest this intervention could be an effective way to prevent the development of postpartum mental health challenges in women living in low-resource settings
3/2/2024
Intervention reduces likelihood of developing postpartum anxiety and depression by more than 70% (3/2/2024)
Results from a large clinical trial funded by the National Institutes of Health show that an intervention for anxiety provided to pregnant women livin...
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A 16-week course of a monoclonal antibody, omalizumab, increased the amount of peanut, tree nuts, egg, milk and wheat that multi-food allergic children as young as 1 year could consume without an allergic reaction in a late-stage clinical trial. Nearly 67% of participants who completed the antibody treatment could consume a single dose of 600 milligrams (mg) or more of peanut protein, equivalent to 2.5 peanuts, without a moderate or severe allergic reaction, in contrast with less than 7% of participants who received placebo
3/2/2024
Antibody reduces allergic reactions to multiple foods in NIH clinical trial (3/2/2024)
A 16-week course of a monoclonal antibody, omalizumab, increased the amount of peanut, tree nuts, egg, milk and wheat that multi-food allergic childre...
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People with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to people who received medical management plus lifestyle interventions, according to a new study supported by the National Institutes of Health. The participants who underwent bariatric surgery, also called metabolic or weight-loss surgery, were also more likely to stop needing diabetes medications and had higher rates of diabetes remission up to 12 years post-surgery
3/2/2024
Bariatric surgery provides long-term blood glucose control, type 2 diabetes remission (3/2/2024)
People with type 2 diabetes who underwent bariatric surgery achieved better long-term blood glucose control compared to people who received medical ma...
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Law enforcement seizures of “magic mushrooms” or “shrooms” containing the psychoactive component psilocybin increased dramatically in the United States between January 2017 and December 2022, according to a new study(link is external) funded by the National Institute on Drug Abuse, part of the National Institutes of Health. The number of law enforcement seizures increased from 402 seizures in 2017 to 1,396 in 2022. In addition, the total weight of psilocybin mushrooms seized by law enforcement increased from 226 kg (498 lbs) seized in 2017 compared to 844 kg (1,861 lbs) in 2022
2/8/2024
Law enforcement seizures of psilocybin mushrooms rose dramatically between 2017-2022 (2/8/2024)
Law enforcement seizures of “magic mushrooms” or “shrooms” containing the psychoactive component psilocybin increased dramatically in the United State...
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Researchers at the National Institutes of Health detected abnormal proteins in the spinal fluid of people with amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD), which could help improve diagnosis of these diseases. The findings were published in Science Translational Medicine
2/8/2024
Abnormal proteins found in the spinal fluid of people with ALS and frontotemporal dementia (2/8/2024)
Researchers at the National Institutes of Health detected abnormal proteins in the spinal fluid of people with amyotrophic lateral sclerosis (ALS) and...
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Researchers at the National Institutes of Health observed rapid and distinct immune system changes in a small study of people who switched to a vegan or a ketogenic (also called keto) diet. Scientists closely monitored various biological responses of people sequentially eating vegan and keto diets for two weeks, in random order
2/8/2024
Switching to vegan or ketogenic diet rapidly impacts immune system (2/8/2024)
Researchers at the National Institutes of Health observed rapid and distinct immune system changes in a small study of people who switched to a vegan ...
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Scientists have unexpectedly discovered that the weakened form of the bacteria Coxiella burnetii (C. burnetii) not typically known to cause disease, naturally acquired an ability to do so. C. burnetii causes Q Fever in humans and its weakened forms are those used for scientific purposes. Subsequently, the scientists identified the genetic mutation responsible for the increased ability to cause disease (virulence) and created a form of the bacteria without the genetic flaw that could safely be used for research
2/8/2024
Researchers create safer form of Coxiella burnetii for scientific use (2/8/2024)
Scientists have unexpectedly discovered that the weakened form of the bacteria Coxiella burnetii (C. burnetii) not typically known to cause disease, n...
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NIH researchers found widespread differences in the brains of children with anxiety disorders that improved after treatment
2/8/2024
Cognitive behavioral therapy alters brain activity in children with anxiety (2/8/2024)
NIH researchers found widespread differences in the brains of children with anxiety disorders that improved after treatmen...
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Researchers at the National Institutes of Health have found overactivation in many brain regions, including the frontal and parietal lobes and the amygdala, in unmedicated children with anxiety disorders. They also showed that treatment with cognitive behavioral therapy (CBT) led to improvements in clinical symptoms and brain functioning. The findings illuminate the brain mechanisms underlying the acute effects of CBT to treat one of the most common mental disorders. The study, published in the American Journal of Psychiatry, was led by researchers at NIH’s National Institute of Mental Health (NIMH)
1/31/2024
Cognitive behavioral therapy alters brain activity in children with anxiety (1/31/2024)
Researchers at the National Institutes of Health have found overactivation in many brain regions, including the frontal and parietal lobes and the amy...
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Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study intended to inform development of a preventive HIV vaccine for people. The antibodies—a human broadly neutralizing antibody and two antibodies isolated from previously vaccinated monkeys—target the fusion peptide, a site on an HIV surface protein that helps the virus fuse with and enter cells. The study, published in Science Translational Medicine, was led by the Vaccine Research Center (VRC) at the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
1/31/2024
NIH-developed HIV antibodies protect animals in proof-of-concept study (1/31/2024)
Three different HIV antibodies each independently protected monkeys from acquiring simian-HIV (SHIV) in a placebo-controlled proof-of-concept study in...
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Researchers at the National Institutes of Health observed rapid and distinct immune system changes in a small study of people who switched to a vegan or a ketogenic (also called keto) diet. Scientists closely monitored various biological responses of people sequentially eating vegan and keto diets for two weeks, in random order. They found that the vegan diet prompted responses linked to innate immunity—the body’s non-specific first line of defense against pathogens—while the keto diet prompted responses associated with adaptive immunity—pathogen-specific immunity built through exposures in daily life and vaccination. Metabolic changes and shifts in the participants’ microbiomes—communities of bacteria living in the gut—were also observed. More research is needed to determine if these changes are beneficial or detrimental and what effect they could have on nutritional interventions for diseases such as cancer or inflammatory conditions
1/31/2024
Switching to vegan or ketogenic diet rapidly impacts immune system (1/31/2024)
Researchers at the National Institutes of Health observed rapid and distinct immune system changes in a small study of people who switched to a vegan ...
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Scientists have unexpectedly discovered that the weakened form of the bacteria Coxiella burnetii (C. burnetii) not typically known to cause disease, naturally acquired an ability to do so. C. burnetii causes Q Fever in humans and its weakened forms are those used for scientific purposes. Subsequently, the scientists identified the genetic mutation responsible for the increased ability to cause disease (virulence) and created a form of the bacteria without the genetic flaw that could safely be used for research
1/31/2024
Researchers create safer form of Coxiella burnetii for scientific use (1/31/2024)
Scientists have unexpectedly discovered that the weakened form of the bacteria Coxiella burnetii (C. burnetii) not typically known to cause disease, n...
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Researchers have linked a decade-long decline in the blood lead levels of American Indian adults to long-term cardiovascular health benefits, including reduced blood pressure levels and a reduction in a marker associated with hypertrophic cardiomyopathy and heart failure. The research, supported by the National Institutes of Health, found that adults who had the greatest reductions in blood lead levels saw their systolic blood pressure fall by about 7 mm Hg, an amount comparable to the effects of blood pressure-lowering medication. Lead exposure is known to harm the health of children by damaging the brain and nervous system and slowing growth and development. It has also been associated with increased risks for heart disease in adults. The findings published in the Journal of the American Heart Association(link is external)
1/31/2024
Reduced blood lead levels linked to lower blood pressure in American Indians (1/31/2024)
Researchers have linked a decade-long decline in the blood lead levels of American Indian adults to long-term cardiovascular health benefits, includin...
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Researchers have discovered that a protein called phosphorylated a-synuclein, which is associated with several neurodegenerative diseases such as Parkinson’s disease and Lewy body dementia, is also involved in the normal processes of how neurons communicate with each other in a healthy brain. The research, published in Neuron, was funded in part by the National Institute of Neurological Disorders and Stroke (NINDS), a part of the National Institutes of Health.
1/10/2024
A common marker of neurological diseases may play role in healthy brains (1/10/2024)
Researchers have discovered that a protein called phosphorylated a-synuclein, which is associated with several neurodegenerative diseases such as Park...
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A monoclonal antibody treatment significantly increased the amounts of multiple common foods that food-allergic children and adolescents could consume without an allergic reaction, according to a planned interim analysis of an advanced clinical trial. The trial is sponsored and funded by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health.
1/10/2024
Antibody reduces allergic reactions to multiple foods in NIH trial (1/10/2024)
A monoclonal antibody treatment significantly increased the amounts of multiple common foods that food-allergic children and adolescents could consume...
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NIH-supported analysis finds just seven states had a facility that accepted Medicaid, had a bed open the same day, and offered buprenorphine.
1/10/2024
Residential addiction treatment for adolescents is scarce and expensive (1/10/2024)
NIH-supported analysis finds just seven states had a facility that accepted Medicaid, had a bed open the same day, and offered buprenorphine...
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Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at the National Institutes of Health and their colleagues. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models
12/15/2023
Calorie restriction in humans builds strong muscle and stimulates healthy aging genes (12/15/2023)
Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health, according to researchers at th...
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The National Institutes of Health is taking steps to simplify its process to assess the scientific merit of research grant applications and mitigate elements that have the potential to introduce bias into review. The changes will help reviewers focus on the potential for proposed research to advance scientific knowledge and improve human health. Previously, five criteria were individually scored using a common scale; the simplified review framework reorganizes these criteria into three factors
11/25/2023
NIH revises grant review process to improve focus on scientific merit, reduce reputational bias (11/25/2023)
The National Institutes of Health is taking steps to simplify its process to assess the scientific merit of research grant applications and mitigate e...
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Starting buprenorphine treatment for opioid use disorder through telehealth was associated with an increased likelihood of staying in treatment longer compared to starting treatment in a non-telehealth setting, according to a new study analyzing Medicaid data from 2019-2020 in Kentucky and Ohio
11/25/2023
Telehealth supports retention in treatment for opioid use disorder (11/25/2023)
Starting buprenorphine treatment for opioid use disorder through telehealth was associated with an increased likelihood of staying in treatment longer...
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A research team funded by the National Institutes of Health has developed a smart phone app that can track and analyze a person’s ability to move from one place to another, known as locomotion, and other types of movements. Human motion analysis is used to evaluate patients with movement difficulties, to help clinicians plan surgery, and to assess the results of treatment procedures
10/19/2023
New smartphone app quickly analyzes human motion to aid physical rehabilitation (10/19/2023)
A research team funded by the National Institutes of Health has developed a smart phone app that can track and analyze a person’s ability to move from...
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Researchers have found that previous studies analyzing the genomes of people with European ancestry may have reported inaccurate results by not fully accounting for population structure. By considering mixed genetic lineages, researchers at the National Human Genome Research Institute (NHGRI), part of the National Institutes of Health, demonstrated that previously inferred links between a genomic variant that helps digest lactose and traits such as a person’s height and cholesterol level may not be valid
9/12/2023
Previous genetic association studies involving people with European ancestry may be inaccurate (9/12/2023)
Researchers have found that previous studies analyzing the genomes of people with European ancestry may have reported inaccurate results by not fully ...
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A new study on the relationship between mobility and income has shown that better mobility was strongly associated with higher income and longer working years in adults. The findings, from researchers at the National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), part of the National Institutes of Health
9/12/2023
Higher income and longer working years are linked to better mobility (9/12/2023)
A new study on the relationship between mobility and income has shown that better mobility was strongly associated with higher income and longer worki...
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NIH study suggests the brain’s “salience network” is important for understanding substance use disorder, could be a future therapeutic target.
8/24/2023
Researchers identify brain network that is uniquely activated through injection vs. oral drug use (8/24/2023)
NIH study suggests the brain’s “salience network” is important for understanding substance use disorder, could be a future therapeutic target...
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The ventilation technique, also known as rescue breathing, commonly used during cardiopulmonary resuscitation (CPR) for people with cardiac arrest is often performed poorly by professional emergency responders, and this ineffective strategy is linked to significantly worse patient survival rates, according to a study supported by the National Institutes of Health.
7/8/2023
Study finds poor ventilation use during CPR for out-of-hospital cardiac arrest (7/8/2023)
The ventilation technique, also known as rescue breathing, commonly used during cardiopulmonary resuscitation (CPR) for people with cardiac arrest is ...
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A study supported by the National Institutes of Health suggests that the response of immune system cells inside the protective covering surrounding the brain may contribute to the cognitive decline that can occur in a person with chronic high blood pressure. This finding, published in Nature Neuroscience, may shed light on new ways to counteract the effects of high blood pressure on cognition
6/19/2023
Salty immune cells surrounding the brain linked to hypertension-induced dementia (6/19/2023)
A study supported by the National Institutes of Health suggests that the response of immune system cells inside the protective covering surrounding th...
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Drug overdose deaths rose markedly between January to June 2018 and July to December 2021 among 10- to 44-year-old girls and women who were pregnant or pregnant within the previous 12 months, according to a new study by researchers at National Institute on Drug Abuse (NIDA) at the National Institutes of Health. Overdose mortality more than tripled among those aged 35 to 44 during the study period, from 4.9 deaths per 100,000 mothers aged 35 to 44 with a live birth in the 2018 period to 15.8 in the 2021 period
6/19/2023
Overdose deaths increased in pregnant and postpartum women from early 2018 to late 2021 (6/19/2023)
Drug overdose deaths rose markedly between January to June 2018 and July to December 2021 among 10- to 44-year-old girls and women who were pregnant o...
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A trial of a new drug regimen to treat tuberculous meningitis (TBM) has started enrolling adults and adolescents in several countries where tuberculosis (TB) is prevalent. The Improved Management with Antimicrobial Agents Isoniazid Rifampicin Linezolid for TBM (IMAGINE-TBM) trial will compare a six-month regimen of four drugs with the nine-month, standard-of-care regimen for TBM. The study aims to generate evidence that could improve treatment for people with TBM
5/20/2023
NIH clinical trial of tuberculous meningitis drug regimen begins (5/20/2023)
A trial of a new drug regimen to treat tuberculous meningitis (TBM) has started enrolling adults and adolescents in several countries where tuberculos...
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Pivotal studies of some biomedical HIV and sexually transmitted infection (STI) prevention interventions have excluded cisgender women or demonstrated low efficacy among them, limiting their prevention options relative to other populations who experience high HIV and STI incidence
4/19/2023
Biomedical STI prevention evidence is inadequate for cisgender women (4/19/2023)
Pivotal studies of some biomedical HIV and sexually transmitted infection (STI) prevention interventions have excluded cisgender women or demonstrated...
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Researchers at the National Institutes of Health have mapped the 3D organization of genetic material of key developmental stages of human retinal formation, using intricate models of a retina grown in the lab. The findings lay a foundation for understanding clinical traits in many eye diseases, and reveal a highly dynamic process by which the architecture of chromatin, the DNA and proteins that form chromosomes, regulates gene expression. The findings were published in Cell Reports.
4/12/2023
NIH study shows how genes in retina get regulated during development (4/12/2023)
Researchers at the National Institutes of Health have mapped the 3D organization of genetic material of key developmental stages of human retinal form...
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Temperature-Stable TB Vaccine Safe, Prompts Immune Response in NIH-Supported Study
3/9/2023
Temperature-Stable TB Vaccine Safe (3/9/2023)
Temperature-Stable TB Vaccine Safe, Prompts Immune Response in NIH-Supported Stud...
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Forgoing one food treats eosinophilic esophagitis as well as excluding six
NIH grantees report results of first multi-site randomized trial comparing the two diets
3/9/2023
Forgoing one food treats eosinophilic esophagitis (3/9/2023)
Forgoing one food treats eosinophilic esophagitis as well as excluding six
NIH grantees report results of first multi-site randomized trial comparing...
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Long-acting antiretroviral therapy suppresses HIV among people with unstable housing, mental illnesses, substance use disorders
NIH-supported study demonstrates injectable ART may improve outcomes in underserved patients
3/9/2023
Long-acting antiretroviral therapy suppresses (3/9/2023)
Long-acting antiretroviral therapy suppresses HIV among people with unstable housing, mental illnesses, substance use disorders
NIH-supported study d...
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A promising approach to control Staphylococcus aureus bacterial colonization in people – using a probiotic instead of antibiotics – was safe and highly effective in a Phase 2 clinical trial. The new study, reported in The Lancet Microbe, found that the probiotic Bacillus subtilis markedly reduced S. aureus colonization in trial participants without harming the gut microbiota, which includes bacteria that can benefit people. The research was conducted by researchers at the National Institutes of Health led by Michael Otto, Ph.D., an NIH senior investigator at the National Institute of Allergy and Infectious Diseases (NIAID).
1/23/2023
Probiotic markedly reduces S. aureus colonization in Phase 2 trial (1/23/2023)
A promising approach to control Staphylococcus aureus bacterial colonization in people – using a probiotic instead of antibiotics – was safe and highl...
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Overdose deaths involving buprenorphine did not proportionally increase with new flexibilities in prescribing
1/23/2023
Overdose deaths involving buprenorphine (1/23/2023)
Overdose deaths involving buprenorphine did not proportionally increase with new flexibilities in prescribing...
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The National Science Advisory Board for Biosecurity (NSABB) will convene virtually on January 27, 2023, to discuss the draft report of the NSABB Working Groups to Review and Evaluate the U.S. Government Potential Pandemic Pathogen Care and Oversight (PC3O) and Dual Use Research of Concern (DURC) Policies. The draft report will be posted on the NSABB website ahead of the meeting. Members of the public may provide comments on the draft report at the meeting or submit comments in writing.
1/23/2023
National Science Advisory Board for Biosecurity to meet (1/23/2023)
The National Science Advisory Board for Biosecurity (NSABB) will convene virtually on January 27, 2023, to discuss the draft report of the NSABB Worki...
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Two drugs widely used to treat adults with heart failure – furosemide and torsemide – showed no difference in their ability to improve patient survival when compared, according to findings from a clinical trial supported by the National Institutes of Health. The trial, one of the largest to date studying routine medications in heart failure, helps resolve a long-standing question about whether one drug is better than the other for treating this group of patients, who carry a high risk of death.
1/23/2023
Comparison of diuretics shows no difference in heart failure survival (1/23/2023)
Two drugs widely used to treat adults with heart failure – furosemide and torsemide – showed no difference in their ability to improve patient surviva...
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An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection against HIV acquisition, an independent data and safety monitoring board (DSMB) has determined. The HPX3002/HVTN 706, or “Mosaico,” Phase 3 clinical trial began in 2019 and involved 3,900 volunteers ages 18 to 60 years in Europe, North America and South America. Based on the DSMB’s recommendation, the study will be discontinued. Participants are being notified of the findings, and further analyses of the study data are planned
1/23/2023
Experimental HIV vaccine regimen safe but ineffective, study finds. (1/23/2023)
An investigational HIV vaccine regimen tested among men who have sex with men (MSM) and transgender people was safe but did not provide protection aga...
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A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective
10/4/2022
Next-generation technology maintains blood glucose levels by automatically delivering insulin. (10/4/2022)
A device known as a bionic pancreas, which uses next-generation technology to automatically deliver insulin, was more effective...
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Large NIH-funded study included participants in North America and Europe.
10/4/2022
Study confirms link between COVID-19 vaccination and temporary increase in menstrual cycle length. (10/4/2022)
Large NIH-funded study included participants in North America and Europe...
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Monica M. Bertagnolli, M.D., started today as the 16th director of the National Cancer Institute (NCI), part of the National Institutes of Health (NIH). She is the first woman to hold the position of NCI director.
10/4/2022
Monica Bertagnolli begins work as 16th director of the National Cancer Institute (10/4/2022)
Monica M. Bertagnolli, M.D., started today as the 16th director of the National Cancer Institute (NCI), part of the National Institutes of Health (NIH...
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A research team funded by the National Institutes of Health has shown that commercially available rapid antigen tests can detect past and present
9/19/2022
NIH Rapid Acceleration of Diagnostics (RADx®) Tech program (9/19/2022)
A research team funded by the National Institutes of Health has shown that commercially available rapid antigen tests can detect past and presen...
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A Phase 3 clinical trial evaluating the antiviral tecovirimat, also known as TPOXX, is now enrolling adults and children with monkeypox infection in the United States. Study investigators aim to enroll more than 500 people from clinical research sites nationwide. Interested volunteers can visit the ACTG website (clinical trial A5418)(link is external) for more information. The trial is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The NIAID-funded AIDS Clinical Trials Group(link is external) (ACTG) is leading the study, which may later expand to international sites. The Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) at NIH is supporting several sites, including through the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT).
9/12/2022
U.S. clinical trial evaluating antiviral for monkeypox begins (9/12/2022)
A Phase 3 clinical trial evaluating the antiviral tecovirimat, also known as TPOXX, is now enrolling adults and children with monkeypox infection in t...
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The National Institutes of Health has issued two new funding opportunities for diagnostic test manufacturers to develop the next generation of COVID-19 tests, with a major focus on accessibility. The funding opportunities are part of the Rapid Acceleration of Diagnostics (RADx) Tech program, managed by the National Institute of Biomedical Imaging and Bioengineering (NIBIB). The new programs may award up to $300 million in funds from the American Rescue Plan Act of 2021 to support the accelerated development of tests and provide regulatory guidance during the COVID-19 pandemic and beyond.
9/12/2022
NIH seeks the next generation of COVID-19 diagnostics (9/12/2022)
The National Institutes of Health has issued two new funding opportunities for diagnostic test manufacturers to develop the next generation of COVID-1...
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A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers. The trial, which will enroll more than 200 adults across eight U.S. research sites, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. JYNNEOS is manufactured by Bavarian Nordic, based in Copenhagen. It is approved by the U.S. Food and Drug Administration for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
9/12/2022
Clinical Trial Evaluating Monkeypox Vaccine Begins (9/12/2022)
A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun...
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A treatment to move blood from the umbilical cord into an infant’s body may improve the overall health of newborns classified as non-vigorous—limp, pale and with minimal breathing, suggests a study funded by the National Institutes of Health. The procedure, known as umbilical cord milking, involves gently squeezing the cord between the thumb and forefinger and slowly pushing the blood into the abdomen. Compared to non-vigorous infants receiving the standard treatment of immediate umbilical cord clamping, infants who underwent cord milking were less likely to need heart and respiratory support, less likely to have a low level of oxygen in the brain, and more likely to have higher levels of hemoglobin, a substance indicating the presence of red blood cells.
9/12/2022
Umbilical cord milking may improve health in non-vigorous term and near-term infants (9/12/2022)
A treatment to move blood from the umbilical cord into an infant’s body may improve the overall health of newborns classified as non-vigorous—limp, pa...
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A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun enrolling adult volunteers. The trial, which will enroll more than 200 adults across eight U.S. research sites, is sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. JYNNEOS is manufactured by Bavarian Nordic, based in Copenhagen. It is approved by the U.S. Food and Drug Administration for the prevention of smallpox and monkeypox disease in adults 18 years of age and older determined to be at high risk for smallpox or monkeypox infection.
9/12/2022
Clinical Trial Evaluating Monkeypox Vaccine Begins (9/12/2022)
A clinical trial evaluating alternative strategies for administering the JYNNEOS monkeypox vaccine to increase the number of available doses has begun...
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Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Leber congenital amaurosis (LCA), a disease that causes blindness in early childhood. Using patient-derived retina organoids (also known as retinas-in-a-dish), the researchers discovered that a type of LCA caused by mutations in the NPHP5 (also called IQCB1) gene leads to severe defects in the primary cilium, a structure found in nearly all cells of the body. The findings not only shed light on the function of NPHP5 protein in the primary cilium, but also led to a potential treatment for this blinding condition. NEI is part of the National Institutes of Health.
9/12/2022
NIH researchers develop gene therapy for rare ciliopathy (9/12/2022)
Researchers from the National Eye Institute (NEI) have developed a gene therapy that rescues cilia defects in retinal cells affected by a type of Lebe...
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Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the Omicron variant of SARS-CoV-2, antibody levels decrease substantially within 3 months, according to new clinical trial data. The findings, published today in Cell Reports Medicine, are from a study sponsored by the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. The trial was led by NIAID’s Infectious Diseases Clinical Research Consortium.
7/27/2022
Vaccine-Induced Immune Response to Omicron Wanes Substantially Over Time (7/27/2022)
Although COVID-19 booster vaccinations in adults elicit high levels of neutralizing antibodies against the Omicron variant of SARS-CoV-2, antibody lev...
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Research supported by the National Institutes of Health shows that cardiovascular-related deaths have declined over the past two decades, but disparities remain. Researchers found that inequities are mostly driven by differences in race and ethnicity, geographic location, and access to care, among other factors. The findings were published in Circulation, and the research was partially funded by the National Heart, Lung, and Blood Institute (NHLBI), part of NIH.
7/27/2022
Cardiovascular-related deaths in the U.S. fall, but disparities remain (7/27/2022)
Research supported by the National Institutes of Health shows that cardiovascular-related deaths have declined over the past two decades, but disparit...
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Loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may drive age-related changes in the retina, according to a new study in mice from the National Eye Institute (NEI). The retina is the light-sensitive tissue at the back of the eye, and aging-associated diseases of the retina, like age-related macular degeneration (AMD), can lead to blindness. This new finding could lead to therapies to prevent AMD and other aging conditions of the retina. The study was published in the International Journal of Molecular Sciences. NEI is part of the National Institutes of Health.
7/27/2022
NIH study finds loss of ‘youth’ protein may drive aging in the eye (7/27/2022)
Loss of the protein pigment epithelium-derived factor (PEDF), which protects retinal support cells, may drive age-related changes in the retina, accor...
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The Centers for Disease Control and Prevention (CDC) has recommended that Novavax’s COVID-19 vaccine be used as another primary series option for adults in the United States ages 18 years and older. The Food and Drug Administration (FDA) previously authorized for emergency use the protein-based vaccine, known as NVX-CoV2373.
7/27/2022
Statement from NIH and BARDA on the Novavax COVID-19 Vaccine (7/27/2022)
The Centers for Disease Control and Prevention (CDC) has recommended that Novavax’s COVID-19 vaccine be used as another primary series option for adul...
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NIH-funded clinical trial finds that starting with a cheaper drug and switching to a more expensive drug as needed leads to good vision outcomes in diabetic macular edema.
7/27/2022
Cardiovascular-related deaths in the U.S. fall, but disparities remain (7/27/2022)
NIH-funded clinical trial finds that starting with a cheaper drug and switching to a more expensive drug as needed leads to good vision outcomes in di...
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An international team of scientists has identified the neural mechanisms through which sound blunts pain in mice. The findings, which could inform development of safer methods to treat pain, were published in Science. The study was led by researchers at the National Institute of Dental and Craniofacial Research (NIDCR); the University of Science and Technology of China, Hefei; and Anhui Medical University, Hefei, China. NIDCR is part of the National Institutes of Health.
7/8/2022
Researchers discover how sound reduces pain in mice (7/8/2022)
An international team of scientists has identified the neural mechanisms through which sound blunts pain in mice. The findings, which could inform dev...
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The eye’s light-sensing retina taps different circuits depending on whether it is generating image-forming vision or carrying out a non-vision function such as regulating pupil size or sleep/wake cycles, according to a new mouse study from the National Eye Institute (NEI) and the National Institute of Mental Health (NIMH). The findings could have implications for understanding how our eyes help regulate mood, digestion, sleep, and metabolism. NEI and NIMH are part of the National Institutes of Health.
7/8/2022
NIH researchers decode retinal circuits for circadian rhythm, pupillary light response (7/8/2022)
The eye’s light-sensing retina taps different circuits depending on whether it is generating image-forming vision or carrying out a non-vision functio...
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A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain’s blood vessels and may lead to short- and long-term neurological symptoms. In a study published in Brain, researchers from the National Institute of Neurological Disorders and Stroke (NINDS) examined brain changes in nine people who died suddenly after contracting the virus.
7/8/2022
Small NIH study reveals how immune response triggered by COVID-19 may damage the brain (7/8/2022)
A study from the National Institutes of Health describes the immune response triggered by COVID-19 infection that damages the brain’s blood vessels an...
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COVID-19 was the third leading cause of death in the United States between March 2020 and October 2021, according to an analysis of national death certificate data by researchers at the National Cancer Institute, part of the National Institutes of Health. The study appears July 5 in JAMA Internal Medicine.
7/8/2022
COVID-19 was third leading cause of death in the United States in both 2020 and 2021 (7/8/2022)
COVID-19 was the third leading cause of death in the United States between March 2020 and October 2021, according to an analysis of national death cer...
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A class of viruses known to cause severe diarrheal diseases – including the one famous for widespread outbreaks on cruise ships – can grow in the salivary glands of mice and spread through their saliva, scientists at the National Institutes of Health have discovered. The findings show that a new route of transmission exists for these common viruses, which afflict billions of people each year worldwide and can be deadly.
7/8/2022
NIH scientists discover norovirus and other “stomach viruses” can spread through saliva (7/8/2022)
A class of viruses known to cause severe diarrheal diseases – including the one famous for widespread outbreaks on cruise ships – can grow in the sali...
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Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders Click here to read more 1/18/2022
Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders (1/18/2022)
Early Stage Testing of Pharmacologic or Device-based Interventions for the Treatment of Mental Disorders
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Innovative ways to provide education on antimicrobial stewardship practices in animals Click here to read more 1/18/2022
Innovative ways to provide education on antimicrobial stewardship practices in animals (U01) Clinical Trial Not Allowed (1/18/2022)
Innovative ways to provide education on antimicrobial stewardship practices in animals
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Notice of Information: Temporary Extension of Eligibility for NHLBI K24 Applicants Due to COVID-19 Click here to read more 1/18/2022
Notice of Information: Temporary Extension of Eligibility for NHLBI K24 Applicants Due to COVID-19 (1/18/2022)
Notice of Information: Temporary Extension of Eligibility for NHLBI K24 Applicants Due to COVID-19
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Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 - Clinical Trial Not Allowed) Click here to read more 1/13/2022
Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 - Clinical Trial Not Allowed) (1/13/2022)
Coordinating Center for the HIV/AIDS and Substance Use Cohorts Program (U24 - Clinical Trial Not Allowed)
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Notice of change to key dates for RFA-MH-22-120: Pilot Practice-based Research for Primary Care Suicide Prevention (R34 Clinical Trial Optional) Click here to read more 1/13/2022
Notice of change to key dates for RFA-MH-22-120:Pilot Practice-based Research for Primary Care Suicide Prevention (R34 Clinical Trial Optional) (1/13/2022)
Notice of change to key dates for RFA-MH-22-120: Pilot Practice-based Research for Primary Care Suicide Prevention (R34 Clinical Trial Optional)
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Notice of Participation of the National Center for Complementary and Integrative Health (NCCIH) in RFA-EY-21-003, BRAIN Initiative-Related Research Education: Short Courses (R25 Clinical Trial Not Allowed) Click here to read more 1/13/2022
BRAIN Initiative-Related Research Education: Short Courses (R25 Clinical Trial Not Allowed) (1/13/2022)
Notice of Participation of the National Center for Complementary and Integrative Health (NCCIH) in RFA-EY-21-003, BRAIN Initiative-Related Research Ed...
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